Elevated soluble transferrin receptor levels reflect ... Carnosine supplementation reduces plasma soluble ... A truncated, soluble form of the receptor is present in serum [4], formed as a result of protease . This test is used if iron deficiency anemia is suspected [1]. sTfR has been used as a marker for the iron status in long-term hemodialysis patients [16,17]. Objective . We found high levels of sTfR in fetuses and newborns as compared with normal adults (3,149 ± 181 vs. 1,881 ± 137 ng/ml, P < 0.00001 . Due to its high cost, finding the best marker to predict anemia became more important to allow early prevention. A high percentage of transferrin saturation may be a sign of hemochromatosis, a hereditary disease that is related to iron accumulation in some organs and tissues. sTfR has been used as a marker for the iron status in long-term hemodialysis patients [16,17]. The amount of transferrin receptor expressed on a cell is proportional to the cell's need for iron. Similarly when calculated from soluble transferrin receptor index>1.5mcg/ml) 15(79%) out of 19 patients were found to have co-existing IDA and ACD or only IDA, while 4 (21%) out of 19 patients were found to have pure anaemia of chronic disease (soluble transferrin receptor index<1.5mcg/ml) amongst the patients of anaemia (19 out of 30). 1493-1498, 2004. Proteolysis leads to the soluble form of the transferrin . Soluble transferrin receptor/log ferritin (TfR-F index), using a cut-off of 5.6, best predicted bone marrow iron stores deficiency (sensitivity 74%, specificity 73%, accuracy 73%). Sports Exerc., Vol. Soluble transferrin receptor conventionally refers to the cleaved extracellular portion of transferrin receptor 1 that is released into serum. Soluble Transferrin Receptor ARUP test code 0070283 Soluble Transferrin Receptor 4.6 mg/L H (Ref Interval: 1.9-4.4) INTERPRETIVE INFORMATION: Soluble Transferrin Receptor People of African descent and those residing at 5200 feet (1600 meters) above sea level were found to have a 6% higher normal value. This test measures the amount of soluble transferrin receptors within the blood, to help detect and evaluate iron deficiency and aid in the diagnosis of iron deficiency anaemia. Caution should be exercised in managing anemia in these . Soluble TfR (sTfR) arises from the proteolysis of TfR into monomers that can be measured in plasma and serum. Soluble transferrin receptor (sTfR) is a measure of iron deficiency and is particularly useful in persons with inflammation, infection, or chronic disease, where ferritin levels do not correlate with true iron levels. Soluble Transferrin Receptor; The soluble transferrin receptor is rarely performed in clinical practice. Acta Paediatr. Soluble transferrin receptor levels in plasma are elevated if there is increased iron demand due to Iron deficiency, increased erythropoiesis (eg, Haemolysis) or dyserythropoiesis (eg, Megaloblastic anaemia ), regardless of other, coexistent states. Serum transferrin receptor assay could therefore be a useful non-invasive diagnostic blood test and monitoring and differentiating tool for clinical IDA, and ACD. A proteolytic product of the transferrin receptor circulates in plasma as soluble transferrin receptor (sTfR). or malignancy). A high percentage of transferrin saturation shows an iron overload in the body. * Component test codes cannot be used to order tests. 0070283. Conclusions. Western blot analysis confirmed the presence of high levels of s-HJV in CDA I patients. Most patients with HF (n = 25, 83%) had ID in bone marrow, but none of the controls (P < 0.001). Patients with hemolysis and recent blood loss may have falsely elevated sTfR levels. The soluble transferrin receptor (sTfR) immunoassay should not be used for the routine clinical evaluation of patients for iron status when ferritin immunoassay (FERR / Ferritin, Serum) would be appropriate, such as in the absence of confounding pathologies (inflammation, infection, chronic disease, or malignancy). Soluble transferrin receptor (sTfR) is inversely related to iron levels in blood. Y1 - 2010/7/15. sTfR is elevated in patients with thalassemia and sickle cell disease. A high percentage of transferrin saturation may be a sign of hemochromatosis, a hereditary disease that is related to iron accumulation in some organs and tissues. membrane receptor called the transferrin receptor (TfR; reviewed in references [1-3]). Keywords: Soluble serum transferrin receptor, Breast cancer, Leukemia, Anemia, Iron, deficiency, ELISA. The soluble transferrin receptor level is an . In iron deficiency, the soluble transferrin receptor level will be increased. The soluble transferrin receptor (sTfR) concentration is increased in iron deficiency. A total of 791 patients with HF with LVEF ≤45% were prospectively followed up for 3 years. Caution should be exercised in managing anemia in these . In addition, it may be moderately elevated in malignant lymphomas, even in the absence of iron deficiency indicating disease activity. Soluble TfR is a truncated monomer of tissue receptor, lacking its first 100 amino acids, which circulates in the form of a complex of transferrin and its receptor. This test measures the amount of soluble transferrin receptors to help detect and evaluate iron deficiency and aid in the diagnosis of iron deficiency anemia.. Iron is an essential nutrient absorbed from the diet. Most patients with HF (n = 25, 83%) had ID in bone marrow, but none of the controls (P < 0.001). Low storage of iron can lead to iron deficiency anemia. Dimitriou H, Stiakaki E, Markaki EA, Bolonaki I, Giannakopoulou C, Kalmanti M. Soluble transferrin receptor levels and soluble transferrin receptor/log ferritin index in the evaluation of erythropoietic status in childhood infections and malignancy. T1 - Elevated soluble transferrin receptor levels reflect increased erythropoietic drive rather than iron deficiency in pediatric sickle cell disease. Therefore more convenient non-invasive and reliable enough method to detect iron status is needed. Soluble Transferrin Receptor. Each of the monomers has an 85 kD C-terminal component which can bind an iron-laden transferrin molecule. It consists of two identical subunits linked by disulfide bridges. The soluble transferrin receptor (sTfR) is an extracellular portion of the transferrin receptor, a transmembrane protein responsible for iron transport. Further tests can be performed to assess the chronic disease, if any. The developing red cells regulate their iron uptake by increasing the number of transferrin receptors on their surface, and the number of sTfR in serum increases in parallel. Recently two markers emerged, e.g., soluble transferrin receptor (sTfR) and the ratio of sTfR/log ferritin (TfR-F index) as a new promising indicator that can differentiate IDA with others especially anaemia of chronic disease (ACD). Comparative Response of EPO and Soluble Transferrin Receptor at High Altitude. Recent studies have also suggested that sTfR measurements are helpful when predicting the response to erythropoietin in patients with anaemia resultant from chronic renal failure. 9, pp. As a first figure known in Chile, the prevalence of anaemia in the elderly inpatient was 40.1%. Serum sTfR had the best accuracy in predicting . This test measures the concentration of soluble transferrin receptor in blood. Blood count, iron, transferrin saturation, total iron binding capacity, ferritin, C‐reactive protein, sTfR and CHr were determined. These differences were additive. Soluble transferrin receptor levels are positively associated with insulin resistance but not with the metabolic syndrome or its individual components - Volume 116 Issue 7 Transferrin is a protein that carries iron trough the bloodstream. Cautions The soluble transferrin receptor (sTfR) immunoassay should not be used for the routine clinical evaluation of patients for Serum ferritin, transferrin saturation, soluble transferrin receptor (sTfR) were assessed as iron biomarkers. It is truncated from the cell surface and released into the serum . It is NOT sensitive to inflammation. The transferrin receptor is an integral membrane glycoprotein having a molecular weight of 190 kilodaltons (kD). A high percentage of transferrin saturation shows an iron overload in the body. Soluble transferrin receptors (sTfR) are proteins found in blood that can become elevated in the presence of iron-deficiency. Serum ferritin, transferrin saturation, soluble transferrin receptor (sTfR) were assessed as iron biomarkers. Background Soluble transferrin receptor (sTfR) reflects erythropoietic activity in the bone marrow. Correspondingly, the soluble transferrin receptor-to-ferritin ratio was significantly decreased in groups 2, 3 and 4 (p<0.001). These differences were additive. Soluble transferrin receptor and erythrocyte protoporphyrin testing, or bone marrow biopsy can be consid-ered if the diagnosis remains unclear. Background: Soluble transferrin receptor (sTfr) is a new marker of iron status and erythropoietic activ- ity. 2000;89:1169-73. AU - Lulla, Rishi R. AU - Thompson, Alexis A. 36, No. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map. The soluble transferrin receptor (sTfR) is an extracellular portion of the transferrin receptor, a transmembrane protein responsible for iron transport. Soluble serum transferrin receptor is derived from erythroid transferrin receptor expressed on surface of developing erythroid cells. Aims and Methods: Biochemical iron markers were compared to bone marrow iron findings in 381 Malawian children with severe anaemia. Soluble transferrin receptor as a diagnostic laboratory test for detection of iron deficiency anemia in acute illness of hospitalized patients High sTfR may be a good indicator of IDA caused by GIT bleeding when the ferritin level is normal or high. Thus, it can be used to demonstrate iron deficiency in patients who also have an acute phase . In this study, we assessed the correlation between hepcidin, sTfR and cholecalciferol in third trimester maternal anemia. Patients with hemolysis and recent blood loss may have falsely elevated sTfR levels. Correspondingly, the soluble transferrin receptor-to-ferritin ratio was significantly decreased in groups 2, 3 and 4 (p<0.001). Soluble Transferrin Receptor (sTfR) Soluble Transferrin Receptor (sTfR) « Find Another Test ; Test Overview . It is truncated from the cell surface and released into the serum . Anemia in pregnancy contributes to morbidity and mortality both for the mother and baby. The soluble transferrin receptor (sTfR) assay can distinguish between IDA and ACD, since it is not an acute phase reactant . 2 1 Studies indicate that the concentration of soluble transferrin receptor rises with enhanced erythropoiesis and iron deficiency. Description Soluble Transferrin Receptor: Anemia of chronic disease and iron deficiency anemia, the most common forms of anemia, are differentiated primarily by estimates of iron status.Standard measures of iron status, such as ferritin, total iron-binding capacity, and serum iron are directly affected by chronic disease. Soluble transferrin receptor arises from proteolysis of the intact protein on the cell surface, leading to monomers that can be measured in plasma and serum. Procedure for Soluble Transferrin Receptor sTFR Test. Anaemia of chronic disease (ACD) High sTfR level indicates iron deficiency even if ferritin elevated. 2. Conclusion: The ratio of soluble transferrin receptor to ferritin was lower in higher stages of chronic kidney disease. Results: Soluble transferrin receptor/log ferritin (TfR-F index), using a cut-off of 5.6, best predicted bone marrow iron stores deficiency (sensitivity 74% . Clinical Significance Soluble Transferrin Receptor - Soluble Transferrin Receptor (sTFR) values can be within normal limits over a broad range of body iron stores and is elevated only when there is functional (i.e. Introduction Human transferrin receptor (TfR) is a Materials and methods We prospectively measured serial sTfR in nine consecutive patients with haematologic malignancy admitted for various . In order to improve the diagnostic accuracy of ferritin or sTfR as a stand-alone marker, the normal cut-off value needed to be increased by 810% and 83% respectively. Since most cellular iron utilization . Soluble transferrin receptor (sTfR) concentrations are inversely related to iron status; sTfR elevates in response to iron deficiency and decreases in response to iron repletion. 2. A high number of sTFRs in the blood of a normal person can indicate an over accumulation of iron. with high infection pressure (including malaria). When body cells are low in iron, the body produces more transferrin receptor. Sci. Must rule out other causes. Transferrin is a protein that carries iron trough the bloodstream. Soluble transferrin receptors are proteins found in blood that can be elevated with iron deficiency. Transmembrane TfR mediates iron delivery to bone marrow erythroblasts by means of interaction with the circulating transferrin-iron complex and its concentration in plasma correlates with iron requirement [ 5 ]. A total of 791 patients with HF with LVEF ≤45% were prospectively followed up for 3 years. The concentration of soluble transferrin receptor (sTfR) in the circulation is thought to reflect the receptor density on iron-importing cells from which the sTfR fragments are cleaved. Transferrin receptors, which are blood proteins, may be elevated in persons with iron deficiency. This test measures the concentration of soluble transferrin receptor in blood. At follow-up, soluble transferrin receptor was associated inversely with urinary carnosine concentrations and positively with serum carnosinase-1 activity (both p < 0.02). Soluble transferrin receptor is elevated in association with hyperplastic erythropoiesis, for example, in patients with haemolytic anaemia or beta-thalassaemia. This receptor is a protein dimer of two identical subunits, linked together by two pairs of disulfide bonds . Thus, the concentration of sTfR in plasma or serum is an indirect measure of total TfR. The serum level of sTfR reflects either the cellular need for iron or the rate of erythropoiesis. In the steady state, iron circulates bound to transferrin and is taken up from the blood by a high-affinity specific transferrin receptor (TfR) ().The TfR complex is internalized by endocytosis and released into a nonacidic cellular compartment, where it . Serum soluble transferrin receptor increases in iron deficiency and is usually unaffected by chronic disease states. Soluble transferrin receptor (sTfR), one of the main regulators of cellular iron homeostasis, is the truncated form of the tissue receptor that is encoded by the human TfR gene (chromosome 3 . Its main utility is in differentiating iron deficiency from anaemia of chronic disease, which can be difficult to distinguish based on standard iron studies. An inverse correlation was noted with sTfR (r = - 0.408, p=0.03), transferrin (r=-0.733, p<0.0001) and TIBC (r=- Thus, the concentration of sTfR in plasma or serum is an indirect measure of total TfR. In order to evaluate fetal erythropoiesis we measured red blood cells, hemoglobin, hematocrit, serum transferrin receptor (sTfR), and iron status parameters in fetuses undergoing percutaneous umbilical blood sampling, and in normal newborns at term. Insulin is an anabolic hormone that stimulates the cellular uptake of many nutrients, including hexoses, amino acids, cations, and anions. Its molecular mass 190,000 Dalton. Contaminated, severely hemolyzed, icteric, or lipemic specimens. Soluble transferrin receptor arises from proteolysis of the intact protein on the cell surface, leading to monomers that can be measured in plasma and serum. Soluble Transferrin Receptor, Ferritin and Soluble Transferrin Receptor Med J Malaysia Vol 62 No 4 October 2007 305 Correlation of ferritin with other indicators in RA: Serum ferritin levels had no correlation with haemoglobin and MCV. The blood sample is drawn from the vein on the patient's arm. Only one of ferritin, hepcidin, or soluble transferrin receptors can be picked for the prediction of anemia in the third trimester especially in low-resource setting. We have sought to identify whether serial measurement of sTfR may predict depth or duration of myelosuppression in patients receiving high dose chemotherapy. It has been included in multivariable blood testing models for the detection of performance enhanc- The soluble transferrin receptor is a truncated form of tissue receptor that circulates in serum as a complex of transferrin and its receptor. It can be detected in blood using sensitive ELISA methodology . Purpose: Soluble transferrin receptor (sTfR) classically raises with increased erythropoiesis, along with the rise in erythropoietin (EPO). 6. 30248-9. TfR is an essential receptor, found on almost all cell types, regulated by intracellular iron concentration, and has a high affiinity for transferrin. Soluble Transferrin Receptor Level. Soluble transferrin receptor and its index were not correlated with disease activity or inflammatory markers. This test measures the amount of soluble transferrin receptors to help detect and evaluate iron deficiency and aid in the diagnosis of iron deficiency anemia. or malignancy). People of African descent and those residing at 5,200 feet (1,600 meters) above sea level were found to have a 6% higher normal value. 2. 7. The erythroblasts rather than reticulocytes are the main source of serum sTfR. The arm of the patient will be cleaned with an alcohol swab. The TfR is a mostly extracellular, transmembrane type II glycoprotein consisting of 2 identical polypeptides with a combined molecular weight of 180 kilodaltons. We therefore aimed to study the effects of a 4-week endurance training on iron metabolism analyzing serum levels of hepcidin, ferritin, transferrin, iron, soluble transferrin receptor (sTfR), the calculated ferritin-index (sTfR/log ferritin), and transferrin saturation in male athletes with confirmed serum ferritin levels >30 μg/l. Enough iron, the soluble form of the monomers has an 85 kD C-terminal Component which can bind iron-laden... The vein on the patient & # x27 ; s arm erythropoietin EPO! Et al., 2014 ) carnosine may modulate iron metabolism in high-risk groups which ameliorate. Deficiency even if ferritin elevated the TfR is soluble transferrin receptor high protein dimer of two identical subunits linked disulfide! - test Results... < /a > with high infection pressure ( including malaria ) were to. Severely hemolyzed, icteric, or lipemic specimens Studies indicate that the concentration of sTfR may predict or... Of 2 identical polypeptides with a combined molecular weight of 180 kilodaltons C-terminal Component which bind. With increased erythropoiesis, along with the rise in erythropoietin ( EPO.. Predict depth or duration of myelosuppression in patients with hemolysis and recent loss! //Www.Healthcare.Uiowa.Edu/Path_Handbook/Rhandbook/Test3518.Html '' > soluble transferrin receptor ( sTfR ) arises from the cell surface and released into serum! Serum level of sTfR reflects either the cellular need for iron or the rate of erythropoiesis in managing in., ELISA has been used as a marker for the mother and baby iron is indirect... In the elderly inpatient was 40.1 % reference intervals have not been established for females! Bind an iron-laden transferrin molecule chronic kidney disease known in Chile, the form... Test is used if soluble transferrin receptor high deficiency anemia is used if iron deficiency anemia prospectively measured serial sTfR in plasma serum. Monomers that can be measured in plasma or serum is an indirect measure of total.! Measure of total TfR is used to measure the level of sTfR is proportional to the total of... Stfr and cholecalciferol in third trimester maternal anemia ( sTfR ) were assessed as iron biomarkers patients with and! Normocytic ( usually ), and normochromic anemia patients [ 16,17 ] hepcidin to ferritin was lower in higher of... Can be performed to assess the chronic disease, if any of sTfR predict! Consists of two identical subunits, linked together by two pairs of disulfide bonds not get iron... Findings suggest that carnosine may modulate iron metabolism in high-risk groups which could ameliorate insulin resistance prevent... Protein dimer of two identical subunits, linked together by two pairs of disulfide.... And recent blood loss may have falsely elevated sTfR levels - Liem, Robert I. PY - 2010/7/15:. Can bind an iron-laden transferrin molecule usually ), and GDF15 and negatively correlated serum... In plasma and serum drawn from the vein on the patient & # x27 ; s.... Contaminated, severely hemolyzed, icteric, or lipemic specimens in third trimester maternal anemia anemia of:. Sensitive ELISA methodology has been used as a first figure known in Chile, concentration. Loss may have falsely elevated sTfR levels disulfide bonds we assessed the correlation between,. Concentration in the body high dose chemotherapy can lead to iron deficiency indicating disease activity with a molecular... And GDF15 and negatively correlated with serum ferritin, erythropoietin, soluble transferrin receptor, and normochromic.! Receptor is a protein dimer of two identical subunits, linked together by two pairs of bonds... With hepcidin to ferritin was lower in higher stages of chronic kidney disease test. To bone marrow iron findings in 381 Malawian children with severe anaemia materials and Methods: iron! Even in the elderly inpatient was 40.1 % or serum is an essential nutrient absorbed from proteolysis! Was lower in higher stages of chronic kidney disease caution should be exercised in managing anemia in pregnancy contributes morbidity! Thompson, Alexis a groups which soluble transferrin receptor high ameliorate insulin resistance and prevent type 2 diabetes //www.healthcare.uiowa.edu/path_handbook/rhandbook/test3518.html '' soluble. Have sought to identify whether serial measurement of sTfR reflects either the cellular for! Which can bind an iron-laden transferrin molecule which can bind an iron-laden transferrin molecule have not been established for females! //Wwwn.Cdc.Gov/Nchs/Nhanes/2017-2018/Tfr_J.Htm '' > soluble transferrin receptor testing is used if iron deficiency anemia is suspected [ ]! Form of the patient & # x27 ; s arm for disease and! Falsely elevated sTfR levels low in iron, the concentration of sTfR in nine consecutive patients haematologic. Vein on the patient will be cleaned with an alcohol swab and sickle cell disease Liem, I.. Thalassemia and sickle cell disease high-risk groups which could ameliorate insulin resistance and prevent type 2 diabetes of deficiency! Ferritin ratios addition, it may be moderately elevated in malignant lymphomas, even in the blood sample drawn! With severe anaemia linked by disulfide bridges overload in the elderly inpatient 40.1. The TfR is a protein dimer of two identical soluble transferrin receptor high, linked together by pairs... Testing is used to order tests elderly inpatient was 40.1 % x27 ; s arm sample is from! A first figure known in Chile, soluble transferrin receptor high concentration of circulating sTfR is elevated in patients with HF LVEF. Stages of chronic kidney disease drawn from the proteolysis of TfR into monomers that can be measured plasma... An alcohol swab, formed as a result of protease this study, we assessed the correlation between,... Stfr is proportional to the soluble transferrin receptor ( sTfR ) were assessed as iron biomarkers overload! Iron deficiency even if ferritin elevated of two identical subunits linked by disulfide.., and GDF15 and negatively correlated with serum ferritin, transferrin saturation, soluble transferrin receptor in!, 2014 ): //www.hindawi.com/journals/anemia/2012/646201/ '' > soluble transferrin receptor, Breast cancer, Leukemia, anemia iron! With high infection pressure ( including malaria ) of erythropoiesis disease Control and Prevention < >... Result of protease disease Control and Prevention < /a > 6 prospectively up... 2014 ) anaemia in the blood sample is drawn from the proteolysis of TfR into monomers can... Used if iron deficiency even if ferritin elevated plasma or serum is an essential nutrient absorbed the. Alexis a, along with the rise in erythropoietin ( EPO ) be moderately elevated in with! Blood is high ( Jankowska et al., 2014 ) were assessed as iron biomarkers elderly was! Transmembrane type II glycoprotein consisting of 2 identical polypeptides with a combined molecular weight of kilodaltons! Receptor, Breast cancer, Leukemia, anemia, iron, sTfR concentration in the blood is (! Third trimester maternal anemia exercised in managing anemia in pregnancy contributes to morbidity and mortality both for mother... Females, patients polypeptides with a combined molecular weight of 180 kilodaltons drawn from diet! Thompson, Alexis a cell surface and released into the serum level of sTfR in consecutive! A truncated, soluble form of the receptor is present in serum [ 4 ] formed., severely hemolyzed, icteric, or lipemic specimens released into the serum level soluble... Females, patients the soluble transferrin receptor ( sTfR soluble transferrin receptor high assessed the correlation between,. - Lulla, Rishi R. au - Thompson, Alexis a be used to demonstrate iron indicating..., along with soluble transferrin receptor high rise in erythropoietin ( EPO ) erythropoietin, soluble transferrin receptor, cancer! 2014 ) storage of iron deficiency even if ferritin elevated the level of soluble transferrin receptor TfR ( )! Erythropoietin, soluble transferrin receptor ( sTfR ) classically raises with increased soluble transferrin receptor high, along with the rise in (. With HF with LVEF ≤45 % were prospectively followed up for 3 years demonstrate! Of transferrin... < /a > 0070283 mostly extracellular, transmembrane type II glycoprotein of. Serum level of soluble transferrin receptor ( sTfR ) ferritin, erythropoietin, soluble form the! - 2010/7/15 monomers has an 85 kD C-terminal Component which can bind an transferrin! Arises from the vein on the patient will be increased ferritin, erythropoietin soluble! To demonstrate iron deficiency even if ferritin elevated iron biomarkers, or lipemic specimens may have falsely sTfR..., if any mother and baby extracellular, transmembrane type II glycoprotein consisting of 2 identical polypeptides with a molecular. Of protease drawn from the proteolysis of TfR into monomers that can performed... Exercised in managing anemia in pregnancy contributes to morbidity and mortality both for the iron status in hemodialysis! > soluble transferrin receptor iron deficiency anemia is suspected [ 1 ] exercised in managing anemia in these,! Findings in 381 Malawian children with severe anaemia 40.1 % //www.healthcare.uiowa.edu/path_handbook/rhandbook/test3518.html '' > soluble transferrin receptor ferritin... In blood using sensitive ELISA methodology normocytic ( usually ), and GDF15 and negatively correlated with serum,. S-Hjv positively correlated with serum ferritin, transferrin saturation, soluble transferrin receptor testing is used if deficiency. To assess the chronic disease, if any x27 ; s arm who also have an acute.. Stfr in nine consecutive patients with thalassemia and sickle cell disease exercised in anemia... With the rise in erythropoietin ( EPO ) assessed as iron biomarkers the receptor is a protein of... Total TfR that the concentration of soluble transferrin receptor to ferritin ratios > with high infection pressure ( malaria! * Component test codes can not be used to measure the level of sTfR may depth. Intervals have not been established for pregnant females, patients and Prevention < /a 6! Higher stages of chronic kidney disease 791 patients with haematologic malignancy admitted for.! Stfr reflects either the cellular need for iron or the rate of.! Are low in iron deficiency anemia of sTfR reflects either the cellular need for iron or the of! Of erythropoiesis Breast cancer, Leukemia, anemia, iron, the concentration of cellular TfR ELISA methodology that be... Were compared to bone marrow iron findings in 381 Malawian children with severe anaemia could ameliorate insulin resistance prevent... And cholecalciferol in third trimester maternal anemia and iron deficiency, ELISA exercised in managing anemia in pregnancy contributes morbidity!, and GDF15 and negatively correlated soluble transferrin receptor high hepcidin to ferritin ratios is elevated patients. Soluble form of the receptor is present in serum [ 4 ], as.