Elevated Soluble Transferrin Receptor (sTfR) in A Patient ... These differences were additive. Serum levels of ferritin, transferrin, soluble transferrin receptor (sTfR), hsCRP, and RBP4 were measured by immunonephelometry. Regulation of cell surface transferrin receptor-2 by iron ... Soluble transferrin receptor levels are positively associated with insulin resistance but not with the metabolic syndrome or its individual components - Volume 116 Issue 7 0070283. Abstract. 1. . Seven patients had chronic progressive active disease (CP-A), six had chronic progressive stable (CP-S), ten had relapsing—remitting active (RR-A) and four had relapsing—remitting stable (RR-S . Human cell surface glycoprotein related to cell proliferation is the receptor for transferrin. Objective: To evaluate the effect of different types and volumes of physical activity on sTfr concentration, variables of iron status (ferritin . Soluble serum transferrin receptor (sTfR) level was determined using Enzyme Linked Immunosorbent Assay (ELISA) with kit from R&D, Biosystems, UK with the hematocrit determined using the automated method by Sysmex 2006 facility. Diagnostic power for soluble transferrin receptor/log ferritin index (0.864) was superior to soluble transferrin receptor (0.768) in iron deficiency anemia recognition. Ricchi P, Meloni A, Costantini S, Spasiano A, Di Matola T, Pepe A, et al. Soluble Transferrin Receptor Level. Mast AE, Blinder MA, Gronowski AM, et al: Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several populations. Interpreting Iron Studies - MedSchool WHO has supported the development of such Soluble transferrin receptor arises from proteolysis of the intact protein on the cell surface, leading to monomers that can be measured in plasma and serum. 30248-9. KEYWORDS: anemia, cholecalciferol, hepcidin, pregnancy, soluble transferrin receptor transferrin receptor levels tend to range from 5 mg/L to 8 mg/L in normal subjects, although the value is heavily dependent upon the commercial assay used (11). Soluble transferrin receptor level: a new marker of iron ... A QC card is provided with each kit and lists the mean value and standard deviation for each control level. The soluble (or serum) transferrin receptor (sTfR) is a circulating truncated form of the membrane receptor protein; it is an 85 kDa glycoprotein forming in serum a 320 kDa complex with diferric transferrin. Cellular uptake of iron bound to its carrier protein transferrin (Tf) is mediated by the transferrin receptor (TfR) [1-3]. De Block CEM, Van Capenhout CM, De Leeuw IH, et al: Soluble transferrin receptor level: a new marker of iron deficiency anemia, a common manifestation of gastric . [Google Scholar] Soluble Transferrin Receptor; The soluble transferrin receptor is rarely performed in clinical practice. Extensively studied, mainly in adults, . Y1 - 2010/7/15. Description. It seems that sTfR level is a better marker of iron status compared with other parameters, because its concentration is less affected by inflammation but could be affected by . Soluble transferrin receptors (sTfRs) are proteins found in the blood that are cleaved from the membrane-bound transferrin receptors found on nearly all cells [42]. for the measurement of serum transferrin receptor (sTfR). cleavage of the extracellular domain, resulting in the formation of a truncated soluble transferrin receptor (sTfR) that circulates freely in the blood. Soluble transferrin receptor levels are positively associated with insulin resistance but not with the metabolic syndrome or its individual components - Volume 116 Issue 7 Clin Chem 1998;44:45-51. Increased levels of transferrin receptors (TfR) and soluble TfR (sTfR) are reliable indicators of iron deficiency anemia and conditions with enhanced erythropoietic activity. Plasma membrane-bound transferrin receptor is released by proteolytic cleavage of the extracellular domain, resulting in the formation of a truncated soluble transferrin receptor (sTfR) that circulates freely in the blood. Iron deficiency causes overexpression of transferrin receptor and sTfR levels, while iron repletion results in decreased sTfR levels. be included. Recently, sTfR levels were proposed as a potential new marker of iron metabolism in cardiovascular diseases. Soluble transferrin receptors (sTfR) are proteins found in blood that can become elevated in the presence of iron-deficiency. The new cut-off point of third trimester sTfR and third trimester hepcidin were established in this study and may be useful for risk assessment and treatment monitoring for anemia in pregnancy. Serum transferrin receptor level was Contaminated, severely hemolyzed, icteric, or lipemic specimens. sTfR is elevated in patients with thalassemia and sickle cell disease. Stasi R, Zinzani L, Galieni P, Lauta VM, Damasio E, Dispensa E, et al. Thus, the concentration of sTfR in plasma or serum is an indirect measure of total TfR. Soluble transferrin receptor levels in plasma are elevated if there is increased iron demand due to Iron deficiency, increased erythropoiesis (eg, Haemolysis) or dyserythropoiesis (eg, Megaloblastic anaemia ), regardless of other, coexistent states. Soluble transferrin receptor (sTfR), one of the main regulators of cellular iron homeostasis, is the truncated form of the tissue receptor that is encoded by the human TfR gene (chromosome 3 . Soluble Transferrin Receptor, Ferritin and Soluble Transferrin Receptor Med J Malaysia Vol 62 No 4 October 2007 305 Correlation of ferritin with other indicators in RA: Serum ferritin levels had no correlation with haemoglobin and MCV. If you have anemia and your sTfR level is elevated, then it is likely that you have iron deficiency anemia. Measurement of ferritin is used for the diagnosis of iron deficiency. Reference intervals have not been established for pregnant females, patients . In another aspect, circulating receptor levels rise in the iron‐depleted status due to the post‐transcriptional induction of TfR expression in the . In iron deficiency, the soluble transferrin receptor level will be increased. These differences were additive. membrane receptor called the transferrin receptor (TfR; reviewed in references [1-3]). If your level is within the normal range, then it is more likely that the your anemia is due to another cause, such as chronic disease or inflammation. Soluble form of transferrin receptor-1 level is associated with the age at first diagnosis and the risk of therapeutic intervention and iron overloading in patients with non-transfusion-dependent thalassemia. Soluble transferrin receptor as a diagnostic laboratory test for detection of iron deficiency anemia in acute illness of hospitalized patients High sTfR may be a good indicator of IDA caused by GIT bleeding when the ferritin level is normal or high. Reference intervals have not been established for pregnant females, patients . Access sTfR QC: The QC kit contains 2 vials for each of 3 levels different control levels of ~10, 25 and 90 nmol/L of human soluble transferrin receptor in a buffered BSA matrix with human plasma and preservatives. 5. De Block CEM, Van Capenhout CM, De Leeuw IH, et al: Soluble transferrin receptor level: a new marker of iron deficiency anemia, a common manifestation of gastric autoimmunity in type 1 diabetes. Soluble TfR is a truncated monomer of tissue receptor, lacking its first 100 amino acids, which circulates in the form of a complex of transferrin and its receptor. to assess the clinical significance of soluble transferrin receptor (sTfR) in hypochromic microcytic anaemia. Krawiec, P.; Pac-Kożuchowska, E. Soluble transferrin receptor and soluble transferrin receptor/log ferritin index in diagnosis of iron deficiency anemia in pediatric inflammatory bowel disease. The concentration of sTfR is an indicator of iron status. METHODS: A cross-sectional was conducted in the current study. As many as 5 mL of blood (2 mL for sTfR and 3 mL for serum iron and ferritin levels) was collected. Transferrin receptors, which are blood proteins, may be elevated in persons with iron deficiency. A truncated, soluble form of the receptor is present in serum [4], formed as a result of protease . Bjerner J, Amlie LM, Rusten LS, Jakobsen E. 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